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Using the cell-permeable PKA inhibitor 14–22 amide (PKI, Figure 4 illustrates that PKI rescued the high glucose-stimulated decrease in GR (Figure 4A), SOD (Figure 4B) and catalase (Figure 4C)

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NNMT plays a crucial role in the methylation of nicotinamide, affecting intracellular nicotinamide adenine dinucleotide (NAD+) metabolism—a key cellular cofactor for redox reactions, DNA repair, and transcriptional regulation